Flecainide-induced arrhythmia in canine ventricular epicardium. Phase 2 reentry?
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چکیده
منابع مشابه
Flecainide-induced arrhythmia in canine ventricular epicardium. Phase 2 reentry?
BACKGROUND We recently reported that sodium channel block can produce opposite effects on action potential duration (APD) and refractoriness in epicardial versus endocardial tissues of the canine ventricle. In addition, strong sodium channel current inhibition was found to cause loss of the action potential dome in epicardium but not endocardium, thus inducing a marked dispersion of repolarizat...
متن کاملFlecainide - Induced Arrhythmia in Canine Ventricular Epicardium Phase 2 Reentry ? Subramaniam
Background. We recently reported that sodium channel block can produce opposite effects on action potential duration (APD) and refractoriness in epicardial versus endocardial tissues of the canine ventricle. In addition, strong sodium channel current inhibition was found to cause loss of the action potential dome in epicardium but not endocardium, thus inducing a marked dispersion of repolariza...
متن کاملHigh [Ca2+]o-induced electrical heterogeneity and extrasystolic activity in isolated canine ventricular epicardium. Phase 2 reentry.
BACKGROUND Elevated intracellular calcium activity is thought to play an important role in arrhythmia induction, particularly during ischemia and reperfusion. Delayed after-depolarization-induced triggered activity and intracellular communication problems are thought to be responsible. METHODS AND RESULTS Increased extracellular calcium levels and rapid pacing are interventions known to eleva...
متن کاملEffect of gallic acid on electrophysiological properties and ventricular arrhythmia following chemical-induced arrhythmia in rat
Objective(s): Ventricular arrhythmias including ventricular tachycardia (VT) and ventricular fibrillation (VF) are the most important causes of mortality rate. Gallic acid (GA) has beneficial effects on cardiovascular diseases. The aim of this study was to evaluate the effects of GA on electrophysiological parameters such as QRS complex, heart rate (HR), PR interval pa...
متن کاملFlecainide induced ventricular fibrillation in a neonate.
CASE DETAILS The baby was born by emergency lower segment caesarean section for fetal tachycardia at 38 weeks of gestation. Birth weight was 2.9 kg and Apgar scores were normal. Heart rate was noticed to be persistently high at 240–260 beats/min and ECG was suggestive of supraventricular tachycardia. The baby was initially symptomatic and was treated with ice pack adenosine but with no response...
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ژورنال
عنوان ژورنال: Circulation
سال: 1993
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.87.2.562